Article
Sex hormones influence ORMDL3 expression: Implications for sex-associated asthma phenotype.
The Journal of allergy and clinical immunology - 1 Mar 2026
Granato Elisabetta, Cerqua Ida, Rossi Antonietta, Riemma Maria Antonietta, Monti Maria Chiara, Ferraro Giusy, Romano Barbara, Nanì Maria Francesca, D'Avino Danilo, Simonelli Martina, Malo Joshua, Polverino Francesca, D'Agostino Bruno, Cirino Giuseppe, Roviezzo Fiorentina
Abstract excerpt
BACKGROUND: Genetic polymorphisms in sphingolipid metabolism, particularly involving the orosomucoid-like 3 (ORMDL3) gene, have been associated with asthma risk. Notably, asthma prevalence and severity exhibit pronounced sex differences, emerging in childhood and persisting into adulthood. However, the molecular mechanisms underlying this sexual dimorphism remain incompletely elucidated. OBJECTIVE: We...
Topics
- Female
- Humans
- Asthma
- Male
- Animals
- Membrane Proteins
- Mice
- Phenotype
- Estradiol
- Lung
- Cell Line