Article
Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact.
Allergy - 1 Oct 2015
Toncheva A A, Potaczek D P, Schedel M, Gersting S W, Michel S, Krajnov N, Gaertner V D, Klingbeil J M, Illig T, Franke A, Winkler C, Hohlfeld J M, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Muntau A C, Kabesch M
Abstract excerpt
BACKGROUND: Genomewide association studies identified ORMDL3 as a plausible asthma candidate gene. ORMDL proteins regulate sphingolipid metabolism and ceramide homeostasis and participate in lymphocyte activation and eosinophil recruitment. Strong sequence homology between the three ORMDL genes and ORMDL protein conservation among different species suggest that they may have shared functions. We hypothesized that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.