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Article

At last - linking ORMDL3 polymorphisms, decreased sphingolipid synthesis, and asthma susceptibility.

The Journal of clinical investigation - 3 Feb 2020

Wills-Karp Marsha

Abstract excerpt

Asthma is a common chronic respiratory disease that has a heritable component. Polymorphisms in the endoplasmic reticular protein orosomucoid-like protein 3 (ORMDL3), which regulates sphingolipid homeostasis, have been strongly linked with childhood-onset asthma. Despite extensive investigation, a link between ORMDL3 asthma-risk genotypes and altered sphingolipid synthesis has been lacking. In this issue of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31929192
DOI: 10.1172/JCI134333
PMCID: PMC6994107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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