Article

A Hidden Markov Modeling Approach for Identifying Tumor Subclones in Next-Generation Sequencing Studies

2019-06-20

Abstract excerpt

Allele-specific copy number alteration (ASCNA) analysis is for identifying copy number abnormalities in tumor cells. Unlike normal cells, tumor cells are heterogeneous as a combination of dominant and minor subclones with distinct copy number profiles. Estimating the clonal proportion and identifying mainclone and subclone genotypes across the genome is important for understanding tumor progression. Several ASCNA...

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Literature Corpus work: bceededa-0ae2-50ec-be89-f8e6a92bddf9
DOI: 10.1101/675512

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