Article
Impute.me: an open source, non-profit tool for using data from DTC genetic testing to calculate and interpret polygenic risk scores
2019-12-02
Abstract excerpt
To date, interpretation of genomic information has focused on single variants conferring disease risk, but most disorders of major public concern have a polygenic architecture. Polygenic risk scores (PRS) give a single measure of disease liability by summarising disease risk across hundreds of thousands of genetic variants. They can be calculated in any genome-wide genotype data-source, using a prediction model ba...
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Identifiers and source
- Literature Corpus work
- 4f90e05a-dfa3-5f70-9e7c-593ba1ec746e
- DOI
- 10.1101/861831