Article

Federated single-cell QTL meta-analysis reveals novel disease mechanisms

2026-01-23

Abstract excerpt

Genetic effects on gene expression are often cell type-specific and obscured in bulk analyses. To resolve this context-dependent regulation, we performed a federated cis- eQTL meta-analysis across 12 PBMC datasets (2,032 individuals, 2.5 million cells). Across six immune cell types, we identified cis- eQTLs for 6,592 genes and fine-mapped 14,985 independent loci. Notably, the 42% of eQTLs that were undetected in...

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Literature Corpus work: 4f89fbd7-89b8-516d-b459-4a48b9ab283e
DOI: 10.64898/2026.01.20.700519

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