Article
Systematic identification of trans eQTLs as putative drivers of known disease associations.
Nature genetics - 1 Oct 2013
Westra Harm-Jan, Peters Marjolein J, Esko Tõnu, Yaghootkar Hanieh, Schurmann Claudia, Kettunen Johannes, Christiansen Mark W, Fairfax Benjamin P, Schramm Katharina, Powell Joseph E, Zhernakova Alexandra, Zhernakova Daria V, Veldink Jan H, Van den Berg Leonard H, Karjalainen Juha, Withoff Sebo, Uitterlinden André G, Hofman Albert, Rivadeneira Fernando, Hoen Peter A C 't, Reinmaa Eva, Fischer Krista, Nelis Mari, Milani Lili, Melzer David, Ferrucci Luigi, Singleton Andrew B, Hernandez Dena G, Nalls Michael A, Homuth Georg, Nauck Matthias, Radke Dörte, Völker Uwe, Perola Markus, Salomaa Veikko, Brody Jennifer, Suchy-Dicey Astrid, Gharib Sina A, Enquobahrie Daniel A, Lumley Thomas, Montgomery Grant W, Makino Seiko, Prokisch Holger, Herder Christian, Roden Michael, Grallert Harald, Meitinger Thomas, Strauch Konstantin, Li Yang, Jansen Ritsert C, Visscher Peter M, Knight Julian C, Psaty Bruce M, Ripatti Samuli, Teumer Alexander, Frayling Timothy M, Metspalu Andres, van Meurs Joyce B J, Franke Lude
Abstract excerpt
Identifying the downstream effects of disease-associated SNPs is challenging. To help overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in non-transformed peripheral blood samples from 5,311 individuals with replication in 2,775 individuals. We identified and replicated trans eQTLs for 233 SNPs (reflecting 103 independent loci) that were previously associated with...
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