Article

A transcriptional patient map of systemic lupus erythematosus reveals disease-related multicellular immune programs conserved between blood and kidney

2026-05-01

Abstract excerpt

Systemic lupus erythematosus (SLE) shows marked clinical and molecular heterogeneity, yet patient stratification often relies on gene expression signatures lacking multicellular context. Here we construct a transcriptional patient map of SLE by analyzing 1,167 total samples (783 SLE, 384 healthy controls) across different resolutions, including single-cell and bulk blood as well as spatially resolved kidney tissue...

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Literature Corpus work: f5259c3c-692e-5a24-86c3-11db3773e112
DOI: 10.64898/2026.04.28.721379

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