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Integrating genomics and AI to uncover molecular targets for mRNA vaccine development in lupus nephritis

4 Oct 2024

Abstract excerpt

Lupus nephritis (LN), a complex complication of systemic lupus erythematosus, requires in-depth cellular and molecular analysis for advanced treatment strategies, including mRNA vaccine development. In this study, we analyzed single-cell RNA sequencing data from 24 LN patients and 10 healthy controls, supplemented by bulk RNA-seq data from additional LN patients and controls. By applying non-negative matrix...

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PMID: 39430760
DOI: 10.3389/fimmu.2024.1381445

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