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Article

Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA.

Nucleic acids research - 1 Jan 2012

Malarkey Christopher S, Bestwick Megan, Kuhlwilm Jane E, Shadel Gerald S, Churchill Mair E A

Abstract excerpt

Mitochondrial transcription factor A (mtTFA/TFAM) is a nucleus-encoded, high-mobility-group-box (HMG-box) protein that regulates transcription of the mitochondrial genome by specifically recognizing light-strand and heavy-strand promoters (LSP, HSP1). TFAM also binds mitochondrial DNA in a non-sequence specific (NSS) fashion and facilitates its packaging into nucleoid structures. However, the requirement and...

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Topics

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Share to DNA-Binding Proteins
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitochondrial Proteins

Share to Nucleic Acid Conformation

Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 21948790
DOI: 10.1093/nar/gkr787
PMCID: PMC3258160

Genes

TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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