Article

The origins and consequences of <i>UPF1</i> variants in pancreatic adenosquamous carcinoma

2020-08-14

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic adenosquamous carcinoma (PASC) is a rare and aggressive subtype of pancreatic cancer whose mutational origins are poorly understood. An early study reported somatic mutations in UPF1 , which encodes a core component of the nonsense-mediated mRNA decay (NMD) pathway, as a common signature of PASC, but subsequent studies did not observe these lesions in other PASC cohorts. The correspo...

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Literature Corpus work: 4ef2f039-2f5d-5b21-a003-b70c44f937ba
DOI: 10.1101/2020.08.14.248864

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