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Article

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma.

eLife - 6 Jan 2021

Polaski Jacob T, Udy Dylan B, Escobar-Hoyos Luisa F, Askan Gokce, Leach Steven D, Ventura Andrea, Kannan Ram, Bradley Robert K

Abstract excerpt

Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but subsequent studies did not observe these lesions. The corresponding controversy about whether UPF1 mutations are important contributors to PASC has been exacerbated by a...

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Identifiers

PMID: 33404013
DOI: 10.7554/eLife.62209
PMCID: PMC7846273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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