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Article

Spliceosomic dysregulation unveils <i>NOVA1</i> as an actionable therapeutic target in pancreatic neuroendocrine tumors

2022-02-10

Abstract excerpt

Dysregulation of the splicing machinery is emerging as a hallmark in cancer due to its association with multiple dysfunctions in tumor cells. Inappropriate function of this machinery can generate tumor-driving splicing variants and trigger oncogenic actions. However, its role in pancreatic neuroendocrine tumors (PanNETs) is poorly defined. In this study we aimed to characterize the expression pattern of a set of s...

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Identifiers and source

Literature Corpus work
fc0471e6-4f41-5e62-b607-656116a58f04
DOI
10.1101/2022.02.09.479525
Open publication

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