Article
The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma.
Nature medicine - 1 Jun 2014
Liu Chen, Karam Rachid, Zhou YingQi, Su Fang, Ji Yuan, Li Gang, Xu GuoTong, Lu LiXia, Wang ChongRen, Song MeiYi, Zhu JingPing, Wang YiRan, Zhao YiFan, Foo Wai Chin, Zuo MingXin, Valasek Mark A, Javle Milind, Wilkinson Miles F, Lu YanJun
Abstract excerpt
Pancreatic adenosquamous carcinoma (ASC) is an enigmatic and aggressive tumor that has a worse prognosis and higher metastatic potential than its adenocarcinoma counterpart. Here we report that ASC tumors frequently harbor somatically acquired mutations in the UPF1 gene, which encodes the core component of the nonsense-mediated RNA decay (NMD) pathway. These tumor-specific mutations alter UPF1 RNA splicing and...
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