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Article

Evolution of the vertebrate DNMT3 gene family: a possible link between existence of <i>DNMT3L</i> and genomic imprinting

1 Jan 2006

Abstract excerpt

DNA methylation plays an essential role in genomic imprinting observed in eutherian mammals and marsupials. In mouse, one of the two de novo DNA methyltransferases, Dnmt3a, and a related protein, Dnmt3L have been shown to be essential for imprint establishment in the parental germline. To gain insights into the evolution of imprinting mechanisms, we have identified and characterized the DNMT3 family genes in...

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Share to Epigenetics and DNA Methylation
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PMID: 16575165
DOI: 10.1159/000090817

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