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Article

A Multiplexed Quantitative Analysis of Germline Single Amino Acid Variants by Targeted Proteomics in Nondepleted Human Plasma.

Journal of proteome research - 1 May 2026

Dakup Panshak P, Lin Tai-Tu, Sarkar Soumyadeep, Schepmoes Athena M, Fillmore Thomas L, Shi Tujin, Qian Wei-Jun, Jacobs Jon M, Consortium A Cps

Abstract excerpt

Single amino acid variants (SAAVs) in protein sequences are often a direct result of single-nucleotide polymorphisms (SNPs). Certain germline SAAVs have shown biological relevance in different disease conditions but lack precise quantification in circulation, which could hinder functional investigations and progress in biomarker development. Here, we have developed a multiplexed liquid chromatography-selected...

Topics

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Blood Proteins
Chromatography, Liquid
Clusterin
CFB gene
CLU gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 41887668
DOI: 10.1021/acs.jproteome.5c00928
PMCID: PMC13140113

Genes

CFB
CLU
FETUB
KNG1
SRM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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