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Article

Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics.

Nature methods - 1 May 2018

Peckner Ryan, Myers Samuel A, Jacome Alvaro Sebastian Vaca, Egertson Jarrett D, Abelin Jennifer G, MacCoss Michael J, Carr Steven A, Jaffe Jacob D

Abstract excerpt

Mass spectrometry with data-independent acquisition (DIA) is a promising method to improve the comprehensiveness and reproducibility of targeted and discovery proteomics, in theory by systematically measuring all peptide precursors in a biological sample. However, the analytical challenges involved in discriminating between peptides with similar sequences in convoluted spectra have limited its applicability in...

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PMID: 29608554
DOI: 10.1038/nmeth.4643
PMCID: PMC5924490

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