Article

A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia

2025-08-27

Abstract excerpt

Microglia engulf dying neurons through efferocytosis, a critical function in both development and disease. How microglia process the engulfed neuronal material—especially lipids—remains poorly understood, despite its central role in neurodegeneration. Thus, we developed HuZIBRA, a scalable in vivo xenotransplantation model in which human iPSC-derived microglia-like cells (iMGLs) are introduced into the developing...

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Literature Corpus work: 4305f106-b7f6-5a9b-9d12-e71c0f95ae74
DOI: 10.1101/2025.08.27.672578

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