Article

A putative role for genome-wide epigenetic regulatory mechanisms in Huntington’s disease: A computational assessment

2017-10-25

Abstract excerpt

<h4>Background: </h4> Huntington's Disease (HD) is an incurable disease of the adult brain. Massive changes in gene expression are a prominent feature. Epigenetic effects have been reported to be implicated in HD, but the role of chromatin is not well understood. We tested if the chromatin state of dysregulated genes in HD is affected at a genome-wide scale and examined how epigenetic processes are associated with...

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Literature Corpus work: 14d57b0c-5013-50a0-a2f9-e569558e1a06
DOI: 10.12688/f1000research.9703.1

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