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Article

Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.

Human molecular genetics - 1 May 2015

Biagioli Marta, Ferrari Francesco, Mendenhall Eric M, Zhang Yijing, Erdin Serkan, Vijayvargia Ravi, Vallabh Sonia M, Solomos Nicole, Manavalan Poornima, Ragavendran Ashok, Ozsolak Fatih, Lee Jong Min, Talkowski Michael E, Gusella James F, Macdonald Marcy E, Park Peter J, Seong Ihn Sik

Abstract excerpt

The CAG repeat expansion in the Huntington's disease gene HTT extends a polyglutamine tract in mutant huntingtin that enhances its ability to facilitate polycomb repressive complex 2 (PRC2). To gain insight into this dominant gain of function, we mapped histone modifications genome-wide across an isogenic panel of mouse embryonic stem cell (ESC) and neuronal progenitor cell (NPC) lines, comparing the effects of...

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Source

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Identifiers

PMID: 25574027
DOI: 10.1093/hmg/ddv006
PMCID: PMC4383859

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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