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Article

Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Apr 2008

Kim Mee-Ohk, Chawla Prianka, Overland Ryan P, Xia Eva, Sadri-Vakili Ghazaleh, Cha Jang-Ho J

Abstract excerpt

Although transcriptional dysregulation is a critical pathogenic mechanism in Huntington's disease (HD), it is still not known how mutant huntingtin causes it. Here we show that alteration of histone monoubiquitylation is a key mechanism. Disrupted interaction of huntingtin with Bmi-1, a component of the hPRC1L E3 ubiquitin ligase complex, increases monoubiquityl histone H2A (uH2A) levels in a cell culture model...

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Identifiers

PMID: 18400894
DOI: 10.1523/JNEUROSCI.5667-07.2008
PMCID: PMC3844822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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