Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.

Cell death and differentiation - 1 Jul 2012

Lee J, Hong Y K, Jeon G S, Hwang Y J, Kim K Y, Seong K H, Jung M-K, Picketts D J, Kowall N W, Cho K S, Ryu H

Abstract excerpt

Aberrant chromatin remodeling is involved in the pathogenesis of Huntington's disease (HD) but the mechanism is not known. Herein, we report that mutant huntingtin (mtHtt) induces the transcription of alpha thalassemia/mental retardation X linked (ATRX), an ATPase/helicase and SWI/SNF-like chromatin remodeling protein via Cdx-2 activation. ATRX expression was elevated in both a cell line model and transgenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDX2 Transcription Factor
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterochromatin

Share to Huntingtin Protein

Share to Huntington Disease

Share to Methylation

Share to RNA, Small Interfering

Share to X-linked Nuclear Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22240898
DOI: 10.1038/cdd.2011.196
PMCID: PMC3374076

Genes

ATRX
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.PMID 22240898Read ↗

From pathology to therapy: A comprehensive review of ATRX mutation related molecular functions and disorders.Semantic proximity Read ↗

ATRX and DAXX: Mechanisms and Mutations.Semantic proximity Read ↗

The Chromatin Remodeler ATRX: Role and Mechanism in Biology and CancerSemantic proximity Read ↗

A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.Semantic proximity Read ↗

Structural basis for DAXX interaction with ATRXSemantic proximity Read ↗

A link between chromatin condensation mechanisms and Huntington's disease: connecting the dots.Semantic proximity Read ↗

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation.Semantic proximity Read ↗

Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s diseaseSemantic proximity Read ↗

ATRX, a guardian of chromatinSemantic proximity Read ↗

Emerging roles of ATRX in cancer.Semantic proximity Read ↗

Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathwaysSemantic proximity Read ↗

[X-linked alpha-thalassemia/mental retardation syndrome].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.