Article
HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2015
Jia Haiqun, Morris Charles D, Williams Roy M, Loring Jeanne F, Thomas Elizabeth A
Abstract excerpt
Increasing evidence has demonstrated that epigenetic factors can profoundly influence gene expression and, in turn, influence resistance or susceptibility to disease. Epigenetic drugs, such as histone deacetylase (HDAC) inhibitors, are finding their way into clinical practice, although their exact mechanisms of action are unclear. To identify mechanisms associated with HDAC inhibition, we performed microarray...
Topics
- Animals
- DNA Methylation
- Disease Models, Animal
- Fibroblasts
- Genetic Loci
- Histone Deacetylase Inhibitors
- Histones
- Humans
- Huntington Disease
- Male
- Mice, Transgenic
- Phenotype
- Real-Time Polymerase Chain Reaction