Article

Prediction of coronavirus 3C-like protease cleavage sites using machine-learning algorithms

2021-08-16

Abstract excerpt

The coronavirus 3C-like (3CL) protease is a Cysteine protease. It plays an important role in viral infection and immune escape by not only cleaving the viral polyprotein ORF1ab at 11 sites, but also cleaving the host proteins. However, there is still a lack of effective tools for determining the cleavage sites of the 3CL protease. This study systematically investigated the diversity of the cleavage sites of the co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4eac8005-11b5-5c51-bcb3-536bcf5753f2
DOI: 10.1101/2021.08.15.456422

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prediction of coronavirus 3C-like protease cleavage sites using machine-learning algorithmsDOI 10.1101/2021.08.15.456422Read

Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirusSemantic proximity Read

Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS‐CoV genomesSemantic proximity Read

Identification of Host Cellular Protein Substrates of SARS-COV-2 Main ProteaseSemantic proximity Read

Predicted coronavirus Nsp5 protease cleavage sites in the human proteomeSemantic proximity Read

The coronavirus 3CL protease: Unveiling its complex host interactions and central role in viral pathogenesisSemantic proximity Read

Predicted Coronavirus Nsp5 Protease Cleavage Sites in the Human Proteome: A Resource for SARS-CoV-2 ResearchSemantic proximity Read

Characterization of host substrates of SARS-CoV-2 main proteaseSemantic proximity Read

3-Chymotrypsin-like Protease (3CLpro): Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical TrialsSemantic proximity Read

Mutational analysis of the active centre of coronavirus 3C-like proteases.Semantic proximity Read

Characterization and Inhibition of the Main Protease of Severe Acute Respiratory Syndrome CoronavirusSemantic proximity Read

Genome-wide Bioinformatics Analysis of Human Protease Specificity Identified Potential Cathepsin L Cleavage Site at K790 Position of the SARS-CoV-2 Spike GlycoproteinSemantic proximity Read

Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in PicornavirusesSemantic proximity Read