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Article

Mutational analysis of the active centre of coronavirus 3C-like proteases.

The Journal of general virology - 1 Mar 2002

Hegyi Annette, Friebe Agnes, Gorbalenya Alexander E, Ziebuhr John

Abstract excerpt

Formation of the coronavirus replication-transcription complex involves the synthesis of large polyprotein precursors that are extensively processed by virus-encoded cysteine proteases. In this study, the coding sequence of the feline infectious peritonitis virus (FIPV) main protease, 3CL(pro), was determined. Comparative sequence analyses revealed that FIPV 3CL(pro) and other coronavirus main proteases are...

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PMID: 11842253
DOI: 10.1099/0022-1317-83-3-581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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