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The coronavirus 3CL protease: Unveiling its complex host interactions and central role in viral pathogenesis

7 Jul 2025

Abstract excerpt

The 3CL protease, a highly conserved enzyme in the coronavirus, plays a crucial role in the viral life cycle by facilitating viral replication through precise cleavage of polyproteins. Beyond its proteolytic function, the 3CL protease also engages in intricate interactions with host cell proteins involved in critical cellular processes such as transcription, translation, and nuclear-cytoplasmic transport,...

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PMID: 40633841
DOI: 10.1016/j.virs.2025.07.002

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