Article

Characterization and Inhibition of the Main Protease of Severe Acute Respiratory Syndrome Coronavirus

2015-02-25

Abstract excerpt

Abstract The main protease of SARS‐associated coronavirus (SARS‐CoV), also called 3C‐like protease (3CLpro), is vital for the viral replication. It cleaves the replicase polyproteins at 11 sites and is a promising drug target. Several groups of inhibitors have been identified through high‐throughput screening and rational drug design. In addition to the pharmaceutical applications, a mutant 3CLpro (T25G) with an e...

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Literature Corpus work: 3216ec2c-3596-5925-b28b-1093a10a3039
DOI: 10.1002/cben.201400031

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