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Characterization of host substrates of SARS-CoV-2 main protease

21 Aug 2023

Abstract excerpt

The main protease (Mpro) plays a crucial role in coronavirus, as it cleaves viral polyproteins and host cellular proteins to ensure successful replication. In this review, we discuss the preference in the recognition sequence of Mpro based on sequence-based studies and structural information and highlight the recent advances in computational and experimental approaches that have aided in discovering novel Mpro...

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PMID: 37670988
DOI: 10.3389/fmicb.2023.1251705

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