Article

Predicted Coronavirus Nsp5 Protease Cleavage Sites in the Human Proteome: A Resource for SARS-CoV-2 Research

2021-06-08

Abstract excerpt

<h4>Background</h4> The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several coronaviruses have also been found to cleave host proteins, disrupting molecular pathways involved in innate immunity. Nsp5 from the recently emerged SARS-CoV-2 virus interacts with and can cleave human proteins, w...

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Literature Corpus work: 40b0ce9c-5091-5fa3-a4eb-0f4f44587508
DOI: 10.1101/2021.06.08.447224

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