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Predicted coronavirus Nsp5 protease cleavage sites in the human proteome

4 Apr 2022

Abstract excerpt

BACKGROUND: The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several coronaviruses have also been found to cleave host proteins, disrupting molecular pathways involved in innate immunity. Nsp5 from the recently emerged SARS-CoV-2 virus interacts with and can cleave human proteins, which may...

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PMID: 35379171
DOI: 10.1186/s12863-022-01044-y

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