Article

Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

2020-06-17

Abstract excerpt

<h4>Background</h4> Chronic hypoxic stress induces epigenetic modifications in cardiac fibroblasts, such as inactivation of tumor suppressor genes (RASSF1A), and activation of kinases (ERK1/2). The effects of the antioxidant enzyme, extracellular superoxide dismutase (EC-SOD), on these epigenetic changes has not been fully explored. <h4>Objectives</h4> To define the effect of EC-SOD overexpression on cardiac fib...

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Literature Corpus work: 4e97a9c7-1fe1-5ede-aaf4-8233dd55df57
DOI: 10.1101/2020.06.16.154302

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