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Article

Redistribution of SOD3 expression due to R213G polymorphism affects pulmonary interstitial macrophage reprogramming in response to hypoxia.

Physiological genomics - 1 Nov 2024

Lewis Caitlin V, Garcia Anastacia M, Burciaga Samuel D, Posey Janelle N, Jordan Mariah, Nguyen Thi-Tina N, Stenmark Kurt R, Mickael Claudia, Sul Christina, Delaney Cassidy, Nozik Eva S

Abstract excerpt

The extracellular isoform of superoxide dismutase (SOD3) is decreased in patients and animals with pulmonary hypertension (PH). The human R213G single-nucleotide polymorphism (SNP) in SOD3 causes its release from tissue extracellular matrix (ECM) into extracellular fluids, without modulating enzyme activity, increasing cardiovascular disease risk in humans and exacerbating chronic hypoxic PH in mice. Given the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39311838
DOI: 10.1152/physiolgenomics.00078.2024
PMCID: PMC11573264

Genes

SOD3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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