Article
Reduced hypoxic pulmonary vascular remodeling by nitric oxide from the endothelium.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2001
Ozaki M, Kawashima S, Yamashita T, Ohashi Y, Rikitake Y, Inoue N, Hirata K I, Hayashi Y, Itoh H, Yokoyama M
Abstract excerpt
We examined whether overproduction of endogenous nitric oxide (NO) can prevent hypoxia-induced pulmonary hypertension and vascular remodeling by using endothelial NO-overexpressing (eNOS-Tg) mice. Male eNOS-Tg mice and their littermates (wild-type, WT) were maintained in normoxic or 10% hypoxic condition for 3 weeks. In normoxia, eNOS protein levels, Ca(2+)-dependent NOS activity, and cGMP levels in the lung of...
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