Article
Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2011
Xu Dachun, Guo Haipeng, Xu Xin, Lu Zhongbing, Fassett John, Hu Xinli, Xu Yawei, Tang Qizhu, Hu Dayi, Somani Arif, Geurts Aron M, Ostertag Eric, Bache Robert J, Weir E Kenneth, Chen Yingjie
Abstract excerpt
Studies have demonstrated that increased oxidative stress contributes to the pathogenesis and the development of pulmonary artery hypertension (PAH). Extracellular superoxide dismutase (SOD3) is essential for removing extracellular superoxide anions, and it is highly expressed in lung tissue. However, it is not clear whether endogenous SOD3 can influence the development of PAH. Here we examined the effect of SOD3...
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