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Article

Extracellular superoxide dismutase deficiency impairs wound healing in advanced age by reducing neovascularization and fibroblast function.

Experimental dermatology - 1 Mar 2016

Fujiwara Toshihiro, Duscher Dominik, Rustad Kristine C, Kosaraju Revanth, Rodrigues Melanie, Whittam Alexander J, Januszyk Michael, Maan Zeshaan N, Gurtner Geoffrey C

Abstract excerpt

Advanced age is characterized by impairments in wound healing, and evidence is accumulating that this may be due in part to a concomitant increase in oxidative stress. Extended exposure to reactive oxygen species (ROS) is thought to lead to cellular dysfunction and organismal death via the destructive oxidation of intra-cellular proteins, lipids and nucleic acids. Extracellular superoxide dismutase (ecSOD/SOD3)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26663425
DOI: 10.1111/exd.12909
PMCID: PMC4998179

Genes

SOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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