Article
Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.
Human molecular genetics - 15 Apr 2014
Watson Chris J, Collier Patrick, Tea Isaac, Neary Roisin, Watson Jenny A, Robinson Claire, Phelan Dermot, Ledwidge Mark T, McDonald Kenneth M, McCann Amanda, Sharaf Osama, Baugh John A
Abstract excerpt
Ischemia caused by coronary artery disease and myocardial infarction leads to aberrant ventricular remodeling and cardiac fibrosis. This occurs partly through accumulation of gene expression changes in resident fibroblasts, resulting in an overactive fibrotic phenotype. Long-term adaptation to a hypoxic insult is likely to require significant modification of chromatin structure in order to maintain the fibrotic...
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