Article

Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

2020-10-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A), and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal transduction critically involved in fibroblast proliferation. RASSF...

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Literature Corpus work: 60a61204-0731-5adf-97a1-dc56ea554cfa
DOI: 10.21203/rs.3.rs-96228/v1

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