Article

HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in a <i>Drosophila</i> model of HIV-related kidney diseases

2024-03-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> People carrying two APOL1 risk alleles (RA) G1 or G2 are at greater risk of developing HIV-associated nephropathy (HIVAN). Studies in transgenic mice showed that the expression of HIV-1 genes in podocytes, and nef in particular, led to HIVAN. However, it remains unclear whether APOL1-RA and HIV-1 Nef interact to induce podocyte cell death. <h4>Method</h4> We generated...

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Literature Corpus work: 4e91967e-a1bf-571e-962f-fe6a0c815cdd
DOI: 10.1101/2024.03.08.584069

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