Article

APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice

2023-03-27

Abstract excerpt

APOL1 high-risk variants partially explain the high kidney disease prevalence among African ancestry individuals. Many mechanisms have been reported in cell culture models, but few have been demonstrated in mouse models. Here we characterize two models: (1) HIV- associated nephropathy (HIVAN) Tg26 mice crossed with bacterial artificial chromosome (BAC)/APOL1 transgenic mice and (2) interferon-ψ administered to BAC...

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Literature Corpus work: 0063c1b8-b01e-53d2-a22b-3b519d9b3b11
DOI: 10.1101/2023.03.27.534273

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