Article
A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome.
Human molecular genetics - 15 Feb 2017
Fu Yulong, Zhu Jun-Yi, Richman Adam, Zhao Zhanzheng, Zhang Fujian, Ray Patricio E, Han Zhe
Abstract excerpt
Many genetic mutations have been identified as monogenic causes of nephrotic syndrome (NS), but important knowledge gaps exist in the roles of these genes in kidney cell biology and renal diseases. More animal models are needed to assess the functions of these genes in vivo, and to determine how they cause NS in a timely manner. Drosophila nephrocytes and human podocytes share striking similarities, but to what...
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