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Article

APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death.

Journal of the American Society of Nephrology : JASN - 1 Apr 2017

Fu Yulong, Zhu Jun-Yi, Richman Adam, Zhang Yi, Xie Xuefang, Das Jharna R, Li Jinliang, Ray Patricio E, Han Zhe

Abstract excerpt

People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of developing renal diseases. However, the mechanisms underlying APOL1-associated renal diseases are unknown. Because the APOL1 gene is unique to humans and some primates, new animal models are needed to understand the function of APOL1 in vivo We generated transgenic Drosophila fly lines expressing the human APOL1 wild type...

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Source

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Identifiers

PMID: 27864430
DOI: 10.1681/ASN.2016050550
PMCID: PMC5373456

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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