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Article

HIV-1 Genes vpr and nef Synergistically Damage Podocytes, Leading to Glomerulosclerosis

20 Sept 2006

Abstract excerpt

This study aimed to identify the causative gene for HIV-1 associated nephropathy, a paradigmatic podocytopathy. A previous study demonstrated that transgenic expression of nonstructural HIV-1 genes selectively in podocytes in mice with FVB/N genetic background resulted in podocyte injury and glomerulosclerosis. In this study, transgenic mice that expressed individual HIV-1 genes in podocytes were generated. Five...

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PMID: 16988066
DOI: 10.1681/asn.2005080878

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