Article

Adipose Triglyceride Lipase protects the endocytosis of renal cells on a high fat diet in <i>Drosophila</i>

2020-11-20

Abstract excerpt

Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic accumulation of lipid droplets in kidney podocytes and in proximal tubule cells. Renal lipid droplets are observed in human CKD patients and in high-fat diet rodent models but their precise role remains unclear. Here, we establish a high-fat diet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47ace86e-1f10-5f59-b71f-6ee5250a6287
DOI: 10.1101/2020.11.19.390146

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adipose Triglyceride Lipase protects the endocytosis of renal cells on a high fat diet in <i>Drosophila</i>DOI 10.1101/2020.11.19.390146Read

JAK-STAT pathway activation compromises nephrocyte function in a <i>Drosophila</i> high-fat diet model of chronic kidney diseaseSemantic proximity Read

Autophagy regulator ATG7 links lipid metabolism to cell-fate decisions in kidney tubule health and diseaseSemantic proximity Read

HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in a <i>Drosophila</i> model of HIV-related kidney diseasesSemantic proximity Read

Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism DisordersSemantic proximity Read

APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes.Semantic proximity Read

APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death.Semantic proximity Read

PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney diseaseSemantic proximity Read

A Drosophila model for Dent's disease type 1 revealed impaired endoplasmic reticulum export of Cubilin as pathogenic mechanism.Semantic proximity Read

A <i>Drosophila</i> model for Dent’s disease reveals impaired ER export of Cubilin as pathogenic mechanismSemantic proximity Read

OCRL regulates lysosomal function and endolysosomal homeostasis in Drosophila nephrocytesSemantic proximity Read

Podocyte endocytosis in the regulation of the glomerular filtration barrierSemantic proximity Read

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasisSemantic proximity Read