Article
APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes.
Journal of the American Society of Nephrology : JASN - 1 Apr 2017
Kruzel-Davila Etty, Shemer Revital, Ofir Ayala, Bavli-Kertselli Ira, Darlyuk-Saadon Ilona, Oren-Giladi Pazit, Wasser Walter G, Magen Daniella, Zaknoun Eid, Schuldiner Maya, Salzberg Adi, Kornitzer Daniel, Marelja Zvonimir, Simons Matias, Skorecki Karl
Abstract excerpt
APOL1 harbors C-terminal sequence variants (G1 and G2), which account for much of the increased risk for kidney disease in sub-Saharan African ancestry populations. Expression of the risk variants has also been shown to cause injury to podocytes and other cell types, but the underlying mechanisms are not understood. We used Drosophila melanogaster and Saccharomyces cerevisiae to help clarify these mechanisms....
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