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Article

APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy.

PloS one - 1 Jan 2019

Bruggeman Leslie A, Wu Zhenzhen, Luo Liping, Madhavan Sethu, Drawz Paul E, Thomas David B, Barisoni Laura, O'Toole John F, Sedor John R

Abstract excerpt

African polymorphisms in the gene for Apolipoprotein L1 (APOL1) confer a survival advantage against lethal trypanosomiasis but also an increased risk for several chronic kidney diseases (CKD) including HIV-associated nephropathy (HIVAN). APOL1 is expressed in renal cells, however, the pathogenic events that lead to renal cell damage and kidney disease are not fully understood. The podocyte function of APOL1-G0...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31661509
DOI: 10.1371/journal.pone.0224408
PMCID: PMC6818796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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