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Article

Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression.

Obesity (Silver Spring, Md.) - 1 Dec 2013

Hoffmeister Albrecht, Tuennemann Jan, Sommerer Ines, Mössner Joachim, Rittger Andrea, Schleinitz Dorit, Kratzsch Jürgen, Rosendahl Jonas, Klöting Nora, Stahl Tobias, Rossner Steffen, Paroni Federico, Maedler Kathrin, Kovacs Peter, Blüher Matthias

Abstract excerpt

OBJECTIVE: Beta-site amyloid precursor protein cleaving enzyme (BACE1) is highly expressed in pancreatic β-cells. The BACE1 gene is located in a region associated with a high diabetes risk in PIMA Indians. DESIGN AND METHODS: INS-1E cells were used to study the impact of siRNA-mediated BACE1 knockdown and glucose metabolism was characterized in Bace1(-/-) mice. BACE1 gene was sequenced in DNA samples from 48...

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Identifiers

PMID: 23596049
DOI: 10.1002/oby.20482

Genes

BACE1
INS

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Related research

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Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression.PMID 23596049Read ↗

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