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Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

18 Apr 2017

Abstract excerpt

BACE1 was discovered as the β-secretase for initiating the cleavage of amyloid precursor protein (APP) at the β-secretase site, while its close homology BACE2 cleaves APP with the Aβ domain region and shows distinct cleavage preferences in vivo. Inhibition of BACE1 proteolytic activity has been confirmed to decrease Aβ generation and amyloid deposition, and thus specific inhibition of BACE1 by small molecules is...

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PMID: 28469554
DOI: 10.3389/fnmol.2017.00097

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