Article
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.
The Journal of biological chemistry - 2 Sept 2005
Dominguez Diana, Tournoy Jos, Hartmann Dieter, Huth Tobias, Cryns Kim, Deforce Siska, Serneels Lutgarde, Camacho Ira Espuny, Marjaux Els, Craessaerts Katleen, Roebroek Anton J M, Schwake Michael, D'Hooge Rudi, Bach Patricia, Kalinke Ulrich, Moechars Dieder, Alzheimer Christian, Reiss Karina, Saftig Paul, De Strooper Bart
Abstract excerpt
Beta-secretase (BACE1) is the rate-limiting protease for the generation of the amyloid beta-peptide (Abeta) in Alzheimer disease. Mice in which the bace1 gene is inactivated are reported to be healthy. However, the presence of a homologous gene encoding BACE2 raises the possibility of compensatory mechanisms. Therefore, we have generated bace1, bace2, and double knockout mice. We report here that BACE1 mice...
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