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Article

BACE1 Structure and Function in Health and Alzheimers Disease

27 Mar 2008

Abstract excerpt

Amyloid plaques, hallmark neuropathological lesions in Alzheimer's disease (AD) brain, are composed of the beta-amyloid peptide (Abeta). Much evidence suggests that Abeta is central to the pathophysiology of AD and is likely to play an early role in this intractable neurodegenerative disorder. Given the strong correlation between Abeta and AD, therapeutic strategies to lower cerebral Abeta levels should prove...

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PMID: 18393796
DOI: 10.2174/156720508783954758

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