Article

Exponential Growth of Glioblastoma <i>In Vivo</i> Driven by Rapidly Dividing and Outwardly Migrating Cancer Stem Cells

2019-08-05

Abstract excerpt

How overall tumor growth emerges from the properties of functionally heterogeneous tumor cell subpopulations is a fundamental question of cancer biology. Here we combined lineage tracing, continuous monitoring of tumor mass, proliferation assays and transcriptomics with mathematical modeling and statistical inference to dissect the growth of glioblastoma in mice. We found that tumors grow exponentially at the rate...

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Literature Corpus work: 4e73453d-4bca-53c6-899e-509c444e9d4a
DOI: 10.1101/723601

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